Laura Camila García Medina*, Maria Patricia Gamero Tafur, Maria Camila Marin Murillo, Yinneth Yasmin Ruiz Atencio, Rosa Angelica Osorio Burgos, Diana Lizeth Grajales Trujillo, Catalina Maria Gutierrez Pico, Jonathan Oscar Reyes Padron
Background: Acral melanoma is a melanoma that occurs on the hands and feet, represents 2 to 3% of all new melanomas, for its diagnosis a narrow margin excisional biopsy is recommended. Ultraviolet radiation is classified as a complete carcinogen, because it is both a mutagen and a non-specific damaging agent and has both tumor initiator and tumor promoter properties.
Methodology: A narrative review was carried out through various databases from January 2009 to January 2022; the search and selection of articles was carried out in journals indexed in English. Keywords were used: Melanoma, Acral, and Ultraviolet.
Results: Acral Lentiginous Melanoma, like mucosal melanomas, is a subtype of melanoma with low mutational load and does not present mutations induced by ultraviolet radiation that are commonly observed in other cutaneous malignant melanomas. Stress or shear force is considered one of the factors for the induction of Acral Lentiginous Melanoma, since the incidence is higher in the weight-bearing areas of the foot.
Conclusions: This review offers updated and detailed information on the association between acral litigious melanoma and ultraviolet exposure, as well as other factors as its triggers.
KeywordsMelanoma; Acral; Ultraviolet
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