转化生物医学

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抽象的

Phosphate buffer-stabilized 0.1% chlorine dioxide-containing mouth wash facilitated sequestration of Bishphosphonate Related Osteonecrosis of jaw (BRONJ) lesion from a patient who presented with Osteonecrosis of the jaw and a history of intravenous bispho

Ehsan Soolari , Amin Soolari , Ahmad Soolari

Background: Inconclusive protocol and consensus exist at present time regarding treatment of patients who have developed Osteonecrosis of the Jaw (ONJ) following administration of intravenous Bisphosphonates. Most clinicians are avoiding treatment for patients presenting with  BRONJ due to lack of predictable treatment outcome.

Findings: In this case report, patient was suffering from a non healing lesion on anterior mandible, which was not responsive to any conventional treatment. Patient was recommended to rinse with the PBSCD for treatment of BRONJ (Bisphosphonate Related Osteonecrosis of the Jaw) lesion seen on some patients who were on intravenous Bisphosphonate medications for multiple myeloma.  Patient was recommended to rinse three times a day with PBSCD. After 4 month use of the solution patient presented with soft tissue healing on previously exposed necrotic bone on mandibular anterior region.

Conclusion: The benefit of Phosphate buffer-stabilized 0.1% chlorine dioxide-containing mouth wash (PBSCD) is discussed. This is a non invasive protocol that has proved to be effective in closing of an open wound.