转化生物医学

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抽象的

Micronutrient Optimization Storage Trial Using Customized Vitamin & Mineral Replacement Therapy Most 2010

Darrin L. Frye

Background: Ultimate health and maximal life span require metabolic harmony and nutrient abundance. Evidence suggests that metabolic damage occurs at intake levels between the level causing micronutrient deficiency diseases and the recommended dietary allowances (RDA). This may result in an increase in DNA damage, neuronal or mitochondrial decay that could lead to accelerated aging, cancers, and degenerative diseases. The optimum amount of vitamins and minerals that are truly required is the amount that minimizes DNA damage and maximizes a healthy life span, which is higher than the amount to prevent acute disease. Maintaining healthy vitamin and mineral stores prevent disease and limit morbidity from them.

Methods: We examined prospectively a cohort of active adults aged 34 to 73 (median 53.5) years of age who were seen at a preventive medicine center in 2009 - 2010. These 10 adult men and women had a comprehensive medical history and baseline and 6 month cellular blood testing utilizing SpectraCell Laboratory’s comprehensive micronutrient method. They were treated therapeutically using IVitaminScience’s (IVS) custom formulation supplementation therapy for six months. Individual nutrient values at six months were compared against their baseline values. Thirteen individual vitamin and ten mineral components that were supplemented based on a proprietary IVitaminScience algorithm. 

Findings: Both men and women showed substantial overall improvement in their vitamins and mineral cellular storage balance. Results of the testing revealed mean deviation from ideal of 15, that decreased from 7.18 (standard deviation 1.12) to 5.73 (standard deviation 2.09) a 20.55% improvement in just six months. 

Conclusions: In a society of nutrient depleted food sources, and poor dietary selection practices, determination of individual nutrient deficiencies and repletion with specific therapeutic doses of vitamins and minerals appears to have promise in restoring and maintaining health. Further studies on vitamin and mineral supplementation targeting disease specific states should be conducted using this model since treatment can be initiated precisely, and objective follow up data can be combined and correlated with clinical findings.