Mai M. Madkour1*, Abd El-Aziz F. Abd El-Aziz1, Fardous F. El-Senduny1, Afaf M. Elsaid2 and Abd ElAziz A. El-Refa
Background: Gestational diabetes mellitus is the most common metabolic disorder that develops during pregnancy. GDM can cause major health problems for the mother both during pregnancy and after the baby is born. In addition, the metabolism of the mother's kids is abnormal. The study aimed to investigate superoxide dismutase 1 genetic variants in pregnant women diagnosed with gestational diabetes using amplification refractory mutation system analysis.
Results: Our study demonstrated that the frequencies of genotypes in women with GDM were SOD1-AG (90.0%). The study revealed there is a significant difference in the frequency of the genotype of SOD1 between GDM and healthy pregnant women.
Conclusions: To the best of our knowledge, this is the first study to indicate that the genotype of SOD1 (A/G rs2070424) has a significant impact on the development of gestational diabetes mellitus in Egyptian women.
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