国际药物开发与研究杂志

  • 国际标准期刊号: 0975-9344
  • 期刊 h 指数: 44
  • 期刊引用分数: 59.93
  • 期刊影响因子: 48.80
索引于
  • Genamics 期刊搜索
  • 中国知网(CNKI)
  • 引用因子
  • 西马戈
  • 研究期刊索引目录 (DRJI)
  • OCLC-WorldCat
  • 普布隆斯
  • 米亚尔
  • 大学教育资助委员会
  • 欧洲酒吧
  • 谷歌学术
  • 夏尔巴罗密欧
  • 秘密搜索引擎实验室
  • 研究之门
分享此页面

抽象的

Formulation and Development of Orodispersible Tablet of Memantine Hydrochloride

Jeevitha M and Pandey VP

The present study aimed to formulate orodispersible tablets of memantine hydrochloride to increase its bioavailability. Orodispersible tablets were prepared by direct compression technique using sublimation approach. The prepared powder mixtures were subjected to both pre and post compression evaluation parameters including; micromeritics properties, tablet hardness, friability, wetting time, disintegration time and in vitro drug release. The results of micromeritics studies revealed that all formulations were of acceptable to good flowability. Tablet hardness and friability indicated good mechanical strength. The F9 formulation which is having high concentration of camphor was given promising results for tablet disintegration, wetting time and gives faster dissolution rate. This increase in the dissolution rate may be due to the presence of crospovidone which is used as a superdisintegrant. This work is helped in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile.