Kabirdas B. Ghorpade*1, Sharda M. Shinde2
The Lyophilisation is also called as Freeze drying where water can be removed from the product with the application of temperature and vacuum. The process of Lyophilisation consists of three steps freezing, primary drying and secondary drying. In the primary drying unbound water is removed from the product after it is froze when placed under vacuum and in secondary drying the bound water which is associated with the drug molecule can be removed by desorption. Determination of the Critical events is very necessary to design and optimize the lyophilisation cycle.
Different studies are involved into the determination of critical events for the design and development of lyophilisation cycle, like FDM, DSC and DTA and impedance analysis. The aim of this study is optimization of the Lyophilisation cycles for Polymixin B using different formulations.
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