Staël Audrey Menteng Tchuenté, Mbiandjeu Tchoumke Marius, Fidèle Djonyabé Bongoro, Fombouot Herman, Ngamli Fewou Simon*
Type II diabetes is a major public health problem with high mortality in low and middle income countries. The presence of anti-diabetic drugs has improved the lives of diabetic patients and only complications such as kidney damage aggravate the disease. Therefore, diagnosis and identification of clinical predictors of the development of renal dysfunction are essential for better disease management. For this reason, we sought to assess the risk factors for renal dysfunction in type II diabetic patients in the NDE hospitals. We conducted a descriptive cross-sectional study in 100 Patients of which 70 were males and 30 females for a sex ratio of 2.33 over a 3-month period from August to October 2021. After completing a questionnaire, parameters such as creatinine and cystatin C were measured by spectrophotometry and nephelometry respectively. Renal function was then assessed by calculating glomerular filtration rate using the MDRD formula. Finally, risk factors were determined using the statistical test of logistic regression. The risk factors obtained after univariate and multivariate analysis were obesity and hypertension. In our population, 19% had moderate renal failure and 12% had severe renal failure. The GFR of the MDRD creatinemia in some patients was significantly higher than that of cystatin C. This would mean that cystatin C is an excellent predictive marker for early renal failure.
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