癌症研究档案

  • 国际标准期刊号: 2254-6081
  • 期刊 h 指数: 13
  • 期刊引用分数: 3.58
  • 期刊影响因子: 3.12
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  • 普布隆斯
  • 日内瓦医学教育与研究基金会
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Analysis of the In Vitro and In Vivo Effects of the Photodynamic Therapy on Prostate Cancer by Using News Photosensitizers, Protoporphyrin IXPolyamines Derivatives

Chloë Fidanzi-Dugas, Bertrand Liagre, Guillaume Chemin, Aurélie Perraud, Claire Carrion, Robert Granet, Vincent Sol and David Yannick Léger

To determine potential mechanisms by which PpIX-PA (protoporphyrin IX-polyamines; PpIX is coupled with two molecules of spermidine (PpIX-dSd) or spermine (PpIX-dSm)) inhibited prostate cancer cell viability, we studied its effects on mitochondrial membrane potential because alterations in mitochondrial structure and function have been shown to play a crucial role at early stages of apoptosis

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