Tavakolian Arjmand*
The overwhelming incidence, the frightening mortality, the economic burden and social life consequences of COVID-19 has put the human being on the edge of an unprecedented catastrophe. In spite of fully-featured pandemic and thorough knowledge regarding the SARS-COV-2 virology, epidemiology, pathogenesis and heterogeneous clinical course of the disease, nothing has been done so far with respect to a noticeable improvement in our treatment strategies, except fighting for face mask, gawn and ventilator, of course. A pre-primitive particle, barely visible even through electron microscope, with a brain of only 29.0 kb, is about to demolish the entire life aspects of highly civilized mankind, pushing them down their chambers in panic and absolute despair. I understand a fellow virologist has named the virus an evil genius primordial life entity. He is right somehow, but I would suggest, confrontation with such an evil thing necessitates an inherent, intuitive and holistic approach. It sounds like we are hypnotized by dreadful spiky silhouette of the virus and become totally distracted from looking towards the weaknesses and fragilities that the virus might have. So far, we have been merely amused with those scanty surface proteins and the tiny genome of the virus. The extremely fragile and pathetically frail virus bilayer phospholipid envelope has been vaguely neglected. We have barely addressed the enormous influence of virus lipid coat on its infective capabilities. We have never thought that even a subtle effort that brings about some biophysical changes in virus lipid envelope may lead to a major achievement reducing the virulence of the bug, and taming the fire-spitting dragon, SARS-COV-2. Enjoying an unstable and ever changing genome, the coronavirus species have been playing hide and seek with us for so many years, and we are still showing renewed enthusiasm to develop enduring vaccine or monoclonal antibodies. It does look somehow eccentric indeed. And so is the fantasy concerning the whole bunch of feeble and failing antiviral agents, old and new. It is a nightmare coming true when we hear that the patients recovered from COVID-19 are still virus shedder and remain positive while retested for RT-PCR. Therefore, counting on convalescent plasma therapy might also be a minor chance if ever. Putting all together, we must look at the problem from an entirely opposite angle. We know beyond doubt that the entire herd of SARS-COV-2 is well within our reach inside the upper and lower respiratory tract. And, the time is tight hence, we are supposed to think about our currently available armaments and use them against the weakest structural aspect of the brand new coronavirus, SARS-COV-2. Based on strong unquestionable biophysical and biological data, I would like to suggest a safe and powerful remedy for COVID-19. Let's play the "Odysseus", and make use of a wooden "Trojan horse" to enter the SARS-COV-2 castle.
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