Sai Kiran
Hematological manifestations of Cobalt toxicity were Polycythemia, Leucopenia, and Thrombocytosis. Polycythemia is usually seen in patients who receive cobalt chloride tablets orally which induces HIF-1 alpha leading to increased erythropoietin levels. With chronic exposure can cobalt rarely leads to decreased expression of Divalent Metal Transporter 1 receptors in the duodenum. This causes decreased absorption of iron from the GI tract and the patient presents with Iron Deficiency Anemia.
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